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REYE

NATIONAL REYE’S SYNDROME FOUNDATION

Reye's Syndrome Bulletin

Reye's Syndrome is a very serious disease. Children and adults develop Reye's Syndrome as they are getting over a viral illness, such as the flu or chicken pox. Reye's Syndrome usually affects people from infancy through young adulthood; however, no age group is immune. Although Reye's generally occurs when someone is recovering from a viral illness, it can develop three to five days after the onset of the illness. The disease's main targets are the liver and brain. Reye's Syndrome is non-contagious, and too often is misdiagnosed as encephalitis, meningitis, diabetes, poisoning, drug overdose, or sudden infant death.

Early diagnosis is crucial. Following a viral illness, individuals should be watched during the next two to three weeks for the following symptoms:

  1. • Relentless or continuous vomiting
  2. • Listlessness (loss of pep and energy)
  3. • Drowsiness (excessive sleepiness)
  4. • Personality change (irritability, slurred speech, sensitivity to touch)
  5. • Disorientation, confusion (unable to identify whereabouts or answer questions)
  6. • Combativeness (striking out at those trying to help them)
  7. • Delirium, convulsions, or loss of consciousness

Reye's syndrome should be suspected in anyone who vomits repeatedly. Call your doctor immediately if these symptoms develop. Voice your concern about Reye's Syndrome. If your physician is unavailable, take the person to an Emergency Room promptly. Two liver function tests (SGOT, SGPT) can be done to determine the possibility of Reye's Syndrome. There is a 90% chance of recovery when the syndrome is treated in its earliest stages by physicians and nurses experienced in the treatment of Reye's.

Studies have shown that using aspirin or aspirin-containing medications to treat the symptoms of viral illnesses increases the chance of developing Reye's Syndrome. If you or a member of your family have a viral illness, do not use aspirin or aspirin-containing medications. In fact, you should consult your physician before you take any drugs to treat any viral illness such as the flu or chicken pox, particularly aspirin or anti-nausea.

The National Reye's Syndrome Foundation (NRSF), the U.S. Surgeon General, the Food and Drug Administration, the Centers for Disease Control, and the American Academy of Pediatrics recommend that aspirin and combination products containing aspirin not be taken by anyone under 19 years of age during fever-causing illnesses.

The NRSF is a nonprofit, tax-exempt organization with affiliates located in 45 states. The NRSF has pioneered the movement to disseminate knowledge about the disease in an effort to aid in early diagnosis and also provides funds for research into the cause, cure, care, treatment, and prevention of Reye's Syndrome.

Aspirin is a part of the salicylate family of medicines. Another name for aspirin is acetylsalicylate; some drug labels may use the words acetylsalicylate, acetylsalicylic acid, salicylic acid, salicylate, etc., instead of the word aspirin. Currently, there is no conclusive data as to whether other forms of salicylates are associated with the development of Reye's Syndrome. Until further research has answered this question, the NRSF recommends that products containing any of these substances not be taken during episodes of viral infections.

National Reye's Syndrome Foundation, Inc. 426 N. Lewis Street PO Box 829 Bryan, OH 43506-0829 E-mail: nrsf@reyessyndrome.org Web: www.reyessyndrome.org Toll Free: 1-800-233-7393 (U.S. only) Telephone: 1-419-636-2679 FAX: 1-419-636-9897 Copyright 2005 National Reye's Syndrome Foundation

Medications Containing Aspirin
(Acetylsalicylate) and Aspirin-Like Products

Epidemiologic research has shown an association between the development of Reye's Syndrome and the use of aspirin-type products for treating symptoms of influenza-like illnesses and chicken pox.  The National Reye's Syndrome Foundation, U.S. Surgeon General, the Food and Drug Administration, and Centers for Disease Control and Prevention recommend that aspirin and combination products containing aspirin not be given to children or teenagers who are suffering from one of these illnesses.  This listing shows products containing aspirin or salicylate compounds.  THIS IS NOT A COMPLETE LIST!  Some medication labels may use the words acetylsalicylate, acetylsalicylic acid, salicylic, salicylamide, phenyl salicylate, etc., instead of the word aspirin.  There is not data as tot other forms of salicylate other than aspirin associated with the development of Reye's Syndrome, but until further research has answered this question, we recommend products listing these substances not be used at all in children and adolescents, because a virus may already be present before symptoms appear.  Product ingredients may be reformulated periodically, so always check the label.  When in doubt ask your doctor or pharmacist.

 

NON-PRESCRIPTION PRODUCTS

PRESCRIPTION PRODUCTS

PRESCRIPTION PRODUCTS (Cont.)

Alka-Seltzer* Bayer   Acuprin 81 Adult Low Dose Aspirin Richwood   Magan Tablets Savage
Anacin* Whitehall Robins   Aggrenox Capsules Boehringer-Ingelheim   Magsal Tablets U.S. Pharmaceutical
Ascriptin* Novartis   Butalbital, Aspirin, Caffeine & Codeine     Methocarbamol & Aspirin Tablets Par
Bayer Aspirin* Bayer     Phosphate Capsules, USP Watson   Mono-Gesic Tablets Schwarz
BC Powder* Block   Carisoprodol and Aspirin Tablets Par   Norgesic Forte Tablets 3M
Bufferin* Bristol-Myers   Darvon Compound-65 Lily   Norgesic Tablets 3M
CVS Aspirin * CVS Pharmacy   Disalcid Capsules and Tablets 3M   Percodan Tablets Endo labs
Doan's* Novartis   Easprin Delayed-Released Tablets Lotus Biochemical   Propoxyphene Compound 65  
Dristan* Whitehall Robins   Endodan Tablets, USP CII Endo Generics     Capsules (CIU) Teva
Ecotrin* SK Beecham   Equagesic Tablets Wyeth-Ayerst   Robaaxisal Tablets Robins
Excedrin* Bristol-Myers   Fiorinal Capsules and Tablets Novartis   Roxiprin Tablets Roxane
Goody's Aspirin* Block   Fiorinal with Codeine Capsules Novartis   Salflex Tablets Carnrick
Kaopectate* Pharmacia   Fiortal with Codeine Capsules Geneva   Salsalate Tablets Duramed
Maalox* Novartis   Gelpirin Tablets Alra   Soma Compound Tablets Wallace
Midol* Bayer   Halfprin Tablets Kramer   Synalgos-DC Capsules Wyeth-Ayerst
Norwich Aspirin* Chattem   Helidac therapy Prometheus Labs   Talwin Compound Sanofi-Wintrhop
Rite Aid Aspirin* Rite Aid   Lobac Capsules and Tablets Seatrace   Trilistate Liquid & Tablets Purdue Frederick
Pamprin* Chattem   Lortab ASA Tablets UCB      
Pepto-Bismol* Proctor and Gamble            
Sine-Off* Hogil Pharmaceutical   *To conserve space on our list, we have listed non-prescription products by brand name only.  Please be aware these products come in many forms, strengths and flavors.  Be sure to check the label for the Reye's Syndrome warning and/or any of the ingredients names listed in the above paragraph.
St. Joseph* Schering-Plough  
Vanquish* Bayer  
YSP* Carlsbad Technology  

The following topical products are listed as they also contain forms of salicylates.  While these products are not ingested through the mouth, certain ingredients may be absorbed through the skin and therefore a potential risk where Reye's Syndrome is concerned.  Be sure to check ingredient labels.  These products are not ingested and as such, not required to carry the aspirin warning.

Acne Cleaners Dandruff Shampoos Muscle Pain Relief Creams
Acne Creams Exfoliating Moisturizers Perfume
Arthritis Pain Rubs Facial Scrubs Sun Block
Astringents Facial Masques Wart Removers
Cosmetics Lotion (Hand & Body) Wintergreen Scented Oils

For More Information Contact the NRSF:

National Reye's Syndrome Foundation, 426 N. Lewis Street, PO Box 829, Bryan, OH
43506-0829

Toll Free:  (800) 233-7393    Local:  (419) 636-2679   
Fax:  (419) 636-9897

Web:  www.reyessyndrome.org   
E-Mail:  nrsf(reyessyndrome.org






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